"A null model for the evolution of the recombination map"Yuksel, MeteRecombination is a subtle process, during which loci are freed of the associations built up by selection and drift. Recent work has underscored how the physical placement of crossovers can alter the extent of genetic shuffling due to recombination: crossovers near the tips of a chromosome shuffle, on average, fewer alleles than crossovers in the middle. We develop a mathematical model to investigate how, under deleterious mutation accumulation, the landscape of recombination evolves. In the model, modifiers of the recombination map land uniformly on the genome and, where they land, a point mass of recombination is added. Using this model, we explore how the frequency of landscape modification, deleterious mutation rate, strength of negative selection, number of crossovers per meiosis, and host-parasite coevolutionary interactions affect the equilibrium recombination landscape. |
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